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Apply now Job no: 495402
Work type: Full-Time
Location: Queen Lane Campus - Philadelphia, PA
Categories: College of Medicine, Drexel University

About Drexel

Drexel is a comprehensive global research university ranked among the top 100 in the nation. With over 24,000 students, Drexel is one of America's 15 largest private universities. Drexel is one of Philadelphia's top 10 private employers, and a major engine for economic development in the region. Drexel has committed to being the nation’s most civically engaged university, with community partnerships integrated into every aspect of service and academics.

Job Summary

The postdoctoral researcher will train in the Department of Microbiology and Immunology to model the various transitional states of the protein pfATP4. He/she will also perform molecular docking and simulation studies to understand the structure-activity relationship between pfATP4 and the 13 different chemotypes that bind to it. He/she will work with MMV partners to develop additional analogs and develop databases of small molecules for screening against additional malaria targets.

Essential Functions

We are looking for talented postdocs to join our team in developing and applying state of the art molecular modeling and machine learning tools for deciphering structure-function of proteins and protein-ligand interactions; structure based/ ligand based screening of combinatorial libraries; QSAR and rational lead optimization to a variety of molecular targets. The position is funded by NIH and offers a vibrant interdisciplinary environment.

• Job Requirements - Ph.D. in computational chemistry / chemistry/ biophysics/ Pharmacology/ bioinformatics/ computer sciences / chemical engineering or a related field
• Demonstrated experience in structural bioinformatics or molecular modeling or computational chemistry and cheminformatics applications to drug design
• Programming and scripting skills in Linux environment (Python, Perl or others) - Hands-on experience with at least one of the major drug discovery software packages (MOE, Schrodinger, OpenEye)
• Experience in molecular dynamics simulations of membrane proteins
• Ability to work with a team of interdisciplinary scientists, excellent verbal and written communication skills

Required Qualifications

Ph.D. in computational chemistry / chemistry/ biophysics/ Pharmacology/ bioinformatics/ computer sciences / chemical engineering or a related field

Location

Center City

Additional Information

This position is classified as Exempt with a salary grade of I. For more information regarding Drexel’s Professional Staff salary structure, https://drexel.edu/hr/career/ducomp/salstructure/

Special Instructions to the Applicant

Please make sure you upload your CV/resume and cover letter when submitting your application.

Review of applicants will begin once a suitable candidate pool is identified.

Advertised: Jan 12 2021 Eastern Standard Time
Applications close: Feb 14 2021 Eastern Standard Time

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